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Explore the comprehensive clinical and pathophysiologic aspects of prostate cancer, one of the most common malignancies affecting men worldwide, in this 35-minute podcast episode. Begin with understanding the epidemiology and key risk factors including age, race, family history, and androgen exposure, then delve into the pathogenesis with particular focus on androgen receptor signaling mechanisms. Examine the clinical manifestations ranging from urinary symptoms to back pain from bone metastases and signs of spinal cord compression. Analyze the utility and ongoing controversy surrounding PSA screening, learn about digital rectal exam findings, and understand the critical importance of prostate biopsy for histologic confirmation with emphasis on Gleason scoring and its prognostic significance. Review essential imaging modalities including multiparametric MRI and bone scans, and explore comprehensive treatment strategies based on risk stratification, covering approaches from active surveillance and radical prostatectomy to radiation therapy and androgen deprivation therapy (ADT).
