Multimodal Molecular Data Storage and Sequencing with Nanopores

Explore cutting-edge nanopore technology applications in molecular data storage and sequencing through this 26-minute conference presentation. Discover how researchers leverage nanopore sequencing adaptability to create innovative solutions for storing, retrieving, and analyzing molecular data across DNA and proteins. Learn about breakthrough developments in DNA data storage, including a rapid, multiplexed random-access method using CRISPR-Cas9 addressing mechanisms to selectively retrieve specific data files encoded in DNA for direct nanopore sequencing. Understand how machine learning enables semantic search capabilities within DNA storage systems by mapping image data into semantic encodings that translate into Cas9-target DNA sequences serving as molecular addresses for high-fidelity similarity searches. Examine emerging applications of nanopore sequencing for protein analysis, including the development of electronic nanopore-based protein sequencing methods aimed at decoding the human proteome. Gain insights into the vision of engineered proteins functioning as programmable molecular recorders, intracellular molecular clocks, and in vivo data storage devices. Discover how these technological advances contribute to establishing a multimodal molecular information ecosystem where nanopores serve as the universal interface for reading, writing, and computing across biological data modalities, presented by Jeff Nivala from the University of Washington at the 2025 Storage and Computing with DNA Conference.