Modeling Informed Drug Development

Explore a comprehensive lecture on pharmacometrics and its impact on drug development from the MfPH Workshop on Endemic COVID-19. Delve into the quantitative pharmacology perspective of drug development, covering topics such as predicting therapeutic modulation, modern methods of molecule selection, dose optimization, and patient-specific considerations. Learn about the MIDD Pilot Program goals and gain insights into demographic variability and genetic modeling. Discover how applied mathematics and modeling techniques are revolutionizing the pharmaceutical industry, from target selection to patient-specific treatments, including a case study on vaccine hyporesponse and immunosenescence discovery.

Syllabus

Intro
PHARMACOMETRICS APPLIED MATHEMATICS IMPACTING DRUG DEVELOPMENT
DRUG DEVELOPMENT A QUANTITATIVE PHARMACOLOGY PERSPECTIVE
RIGHT PATHWAY / RIGHT TARGET PREDICTING THERAPEUTIC MODULATION REQUIRES MODELING
RIGHT MOLECULE PREVIOUS PARADIGM OF CHEMICAL LIBRARIES SUPPLANTED BY NEW METHODS REQUIRING MATHEMATICAL MODELING
RIGHT DOSE BUILDING INFLUENCE VIA QUALITY CONTROL AND CASE STUDIES
GOALS OF THE MIDD PILOT PROGRAM
RIGHT PATIENT DEMOGRAPHIC VARIABILITY, GENETIC MODELING
ACKNOWLEDGEMENTS VACCINE HYPORESPONSE/IMMUNOSENESCENCE DISCOVERY