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Explore the fundamentals of clinical pharmacology through this comprehensive lecture series that covers rational drug development and utilization in therapeutics as a translational scientific discipline. Master core pharmacokinetic and pharmacodynamic concepts including drug absorption, bioavailability, multicompartmental modeling, and population pharmacokinetics while examining the biochemical mechanisms underlying drug toxicity and therapeutic protein pharmacology. Delve into critical pathways of drug metabolism, membrane transport systems, and P-glycoprotein-mediated drug interactions, with special focus on transport across the blood-brain barrier. Analyze pharmacokinetic considerations across diverse patient populations including those with renal impairment requiring hemodialysis or renal replacement therapy, pregnant and nursing women, pediatric patients, geriatric populations, and obese individuals. Investigate advanced topics in pharmacogenomics, pharmacometabolomics, and dose modifications based on genetic research, while exploring clinical drug interactions and adverse drug reaction assessment. Examine cutting-edge developments in drug discovery through quantitative systems pharmacology, computational methods, combinatorial screening, and natural products research. Study drug formulation and delivery systems, biologics development considerations, and FDA approval processes, alongside specialized areas including immunotherapeutics, T-cell therapies, and positron emission tomography applications in pharmacokinetics. Apply theoretical knowledge through practical case studies covering mass spectrometry applications, protein drug pharmacokinetics, transporter-mediated interactions, population modeling exercises, and immunotherapy-related adverse events, while addressing ethical considerations in both pediatric and adult clinical pharmacology research and practice.
