Hybrid Cellular Potts Modeling of Cell-Extracellular Matrix Interactions Driving Cell Shape, Cell Migration and Collective Cell Behavior

Watch a detailed seminar presentation exploring the application of hybrid cellular Potts modeling to understand cell-extracellular matrix interactions and their impact on cell behavior. Delve into how mathematical and computational approaches combine with experimental methods to analyze complex cellular processes. Learn about the cellular Potts model (CPM) framework and its coupling with microenvironment simulations to study individual and collective cell behaviors. Explore specific applications including immune cell migration patterns, cell shape responses to matrix stiffness, force transduction in fibrous ECMs, and anisotropic force generation. Discover how single-cell modeling insights translate to understanding multicellular development, with particular focus on angiogenesis modeling and the role of focal adhesions in cell-ECM interactions. Gain insights into ongoing work on experimental validation methods and computational improvements aimed at developing more sophisticated multicellular models.