Explore groundbreaking research on pancreatic cancer through a one-hour seminar presented by Professor Laura Machesky from the CRUK Beaton Institute at the University of Glasgow. Delve into the critical relationship between mechanosensing and cancer cell behavior in the pancreatic tumor microenvironment. Learn about recent discoveries connecting force sensing, invasive migration, and metabolic dynamics in pancreatic cancer cells, which currently has a devastating 5-year survival rate below 10%. Understand how tumor cells adapt to highly fibrotic extracellular matrices and how this adaptation correlates with metastatic spread to vital organs. Examine the molecular mechanisms that enable cancer cells to align their cytoskeletal polarity with metabolic machinery, and discover potential new approaches for targeting pancreatic cancer's aggressive nature and metastatic potential.