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Algorithms for Metabolic Pathway Discovery in Human Microbiome

Broad Institute via YouTube

Overview

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Join a comprehensive research presentation featuring two talks on microbiome metabolic analysis and computational approaches. Begin with Marnix Medema's primer on deciphering the chemical language of microbiomes, exploring how specialized metabolites influence microbiome ecology and natural product drug discovery. Learn about cutting-edge computational and AI methods for mapping biosynthetic diversity, predicting chemical structures, and identifying key microbiome-associated phenotypes. Continue with Victoria Pascal's detailed discussion of metabolic pathway discovery in the human microbiome, introducing innovative tools like gutSMASH for metabolic profiling and BiG-MAP for analyzing gene cluster abundance and expression. Discover how these computational approaches and algorithms are advancing our understanding of microbe-host interactions and the complex chemistry of microbial communities, with practical applications in both human and plant microbiomes.

Syllabus

MIA: V. Pascal, Algorithms for metabolic pathway discovery in human microbiome; Primer: M. Medema

Taught by

Broad Institute

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