Linking Structure and Function in the Pop Condensate
Kavli Institute for Theoretical Physics via YouTube
Overview
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Explore how biomolecular condensates coordinate cellular activities through their physical properties in this 46-minute conference talk. Discover the mechanisms by which cells concentrate specific molecules into membrane-less compartments that participate in diverse biological functions including gene expression, signal transduction, and neurotransmission. Learn about the wide range of lifetimes, sizes, mechanochemical properties, and architectures exhibited by these condensates, and examine the current understanding of how molecular interactions lead to condensation. Investigate the poorly understood connection between the emergent physical properties of condensates and their biological functions. Gain insights into theoretical frameworks and simulation approaches for describing biomolecular condensates, new experimental methods for characterizing condensates and delineating their functions, and physicochemical principles shaping condensates. Address the challenges in mapping computational and laboratory-based droplet studies to condensates inside living cells, contributing to the cross-disciplinary understanding of this rapidly evolving field in cellular biology and biophysics.
Syllabus
Linking Structure and Function in the Pop Condensate | Keren Lasker (Scripps Institute)
Taught by
Kavli Institute for Theoretical Physics