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Watch a 27-minute webinar exploring innovative approaches to large genomic insertions in mammalian cells, presented by MIT PhD candidate Cian Schmitt-Ulms. Discover PASTE (programmable addition via site-specific targeting elements), a groundbreaking genome editing technique that combines CRISPR-Cas9 nickase with reverse transcriptase and serine integrase capabilities. Learn about the development, engineering, and optimization of PASTE systems for improved efficiency in targeted genomic integration. Explore practical therapeutic applications, particularly in treating monogenic disorders, through this comprehensive presentation from a researcher whose work has been published in prestigious journals including Science and Nature Biotechnology.
