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Explore a comprehensive keynote presentation examining how molecular engineering is revolutionizing immunotherapy development and application. Learn about structure-based protein engineering approaches that address the limitations of naturally occurring therapeutic molecules, including issues with delivery, resistance, and toxicity. Discover how researchers are applying structural and mechanistic insights to redesign existing proteins and create entirely new therapeutic molecules that can more precisely modulate immune responses. Examine the engineering of immune proteins such as cytokines, growth factors, and antibodies for targeted treatment of cancer, autoimmune disorders, and regenerative medicine applications. Understand the transition from traditional unbiased protein engineering approaches to sophisticated structure-function relationship-guided molecular design using cutting-edge structural biology tools and technologies. Gain insights into the mechanistic determinants of protein activity and how this knowledge informs therapeutic development strategies. Follow the complete pipeline from discovery and design through translation of novel molecular immunotherapeutics, with practical examples spanning multiple disease applications. Participate in a live Q&A session with Dr. Jamie Spangler, Associate Professor of Biomedical Engineering and Chemical & Biomolecular Engineering at Johns Hopkins University, whose research focuses on engineering immune molecules for therapeutic applications. Earn PACE continuing education credits while exploring how molecular engineering approaches are addressing clinically unmet needs in immunotherapy and creating new opportunities for precision medicine interventions.
