Enhancing Reproducibility in Humanized Immune System Mouse Models - Foundations and Tailored huSelect Strategies

Explore the foundations and advanced strategies for improving reproducibility in humanized immune system mouse models through this 49-minute keynote webinar. Learn about the critical role of HIS mouse models in translational research across immuno-oncology, autoimmune disorders, and infectious disease applications. Discover the NOG platform with CD34+ hematopoietic stem cell engraftment, understanding both the benefits and limitations of HSC-based humanization approaches. Examine key experimental design considerations and how model selection directly impacts study duration and translational relevance of research outcomes. Address the major challenge of donor-related variability that complicates data interpretation and reproducibility in HIS model research. Gain insights into Taconic's huSelect™ suite of services, including HLA-based donor selection strategies, access to pre-characterized CD34+ HSC donors, and expanded immune profiling capabilities using flow cytometry techniques. Presented by Dr. Philip Dubé, a scientist with over 20 years of experience in rodent model applications, specializing in mouse models for immunology, oncology, immuno-oncology, and inflammatory bowel disease research.