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Explore NASA's groundbreaking application of Unreal Engine technology in this 37-minute conference talk from Unreal Fest Orlando 2025. Discover how the Center for Design and Space Architecture (CDSA) at NASA leverages virtual reality to create high-fidelity simulations of the Gateway Space Station, utilizing advanced Nanite technology to integrate complex, large polygon-count meshes of spaceflight hardware and equipment. Learn about the innovative Human-in-the-Loop (HITL) testing methodology where astronauts simulate critical daily tasks including conducting scientific experiments, retrieving supplies, and preparing meals within the virtual environment, replicating real-world scenarios planned for the Artemis missions. Understand how these immersive simulations combine detailed virtual models with direct astronaut feedback to provide crucial insights that refine station design for optimal safety, functionality, and crew comfort. Gain insights into the Simulation and Graphics Branch's (ER7) extensive history of providing flight operations and astronaut training capabilities, and see how physics-based simulations and immersive technology enable engineers to develop relevant environments for mission analysis, planning, and training preparation for future space exploration endeavors.