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Explore how to transform hope into meaningful action through this 30-minute TED Intersections conversation between immunology researcher David Fajgenbaum and public health expert Celina de Sola. Discover how these leaders scaled their personal missions into organizations creating long-term community impact both locally and globally. Learn strategies for maintaining motivation while staying realistic about necessary work, uncover your unique leadership style, and identify overlooked solutions that may be hiding in plain sight. Gain insights into balancing optimism with pragmatism as you work toward systemic change and sustainable impact in your field or community.