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Explore the intricacies of Hereditary Angioedema (HAE) in this comprehensive 18-minute video lecture. Delve into the autosomal dominant disorder characterized by C1 esterase inhibitor deficiency or dysfunction, leading to increased bradykinin levels. Learn about the pathophysiology, including the role of plasma kallikrein and high molecular weight kininogen in the kallikrein-kinin system. Discover the clinical manifestations, such as angioedema, dry cough, and abdominal pain. Understand the diagnostic approach, including patient history, physical examination, and laboratory tests. Gain insights into treatment strategies, emphasizing the importance of airway management. The lecture covers the contraindication of ACE inhibitors and provides a thorough overview of the coagulation pathway, side effects, and signs and symptoms associated with HAE.
