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Learn to implement standardized antigen-specific T cell response assays for multicenter immune therapy trials in this 59-minute webinar presented by Dr. Megan Levings and Dr. Timothy Tree. Discover how harmonizing immunophenotyping assay designs enables integration of findings across trials, facilitating biomarker identification and validation while revealing cohort-specific features and drug mechanisms. Explore the critical role of antigen-specific T cell response characterization in immunological investigations and patient stratification for future trials. Master robust immune assay techniques designed to detect and characterize rare antigen-specific immune responses directly in peripheral blood, including multimer TCR staining, antigen-induced marker (AIM) assays, and immune cell cytokine production assessment. Examine strategies to reduce inter-laboratory variability in multicenter studies through informative assay designs and complementary methodology utilizing pre-mixed dried antibody panels and dried stimulation mixes with standardized protocols. Review practical applications of these principles through recently published research on T1D autoimmunity studies, including insights from Tatovic et al.'s work published in Nature Medicine 2024.
