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Explore the critical role of biorepositories in advancing immuno-oncology research through this 32-minute webinar presented by Dr. Bradley Mills, PhD, Assistant Professor of Surgery and Director of the Wilmot Cancer Institute Biobank at the University of Rochester Medical Center. Learn how biorepositories provide essential specimens that offer crucial insights into complex tumor-immune interactions, addressing the challenge that over 85% of immunotherapy drugs fail in clinical trials due to biological complexity and substantial interpatient variability. Discover the types of samples commonly available through biorepositories, including tumors from various origins and paired tissue or fluid samples, while understanding how collection protocols must pose no greater than minimal risk to donors. Examine how yield limitations influence sample preservation diversity and quality, directly impacting assay feasibility and success. Gain insights into breakthrough advancements in analytical techniques that maximize value from available samples, including revolutionary developments in genomics and spatial imaging that analyze tumor-immune dynamics both locally and systemically. Understand how innovative preclinical modeling enables deeper investigation into drug responses and biological mechanisms within the human tumor microenvironment. Explore emerging technologies and model systems designed to maximize the scientific value of these limited but precious resources, and discover the strong rationale and opportunities for enhancing the next generation of immuno-oncology discoveries through strategic biospecimen research approaches.
