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Explore the critical issue of neurodegeneration as a global health emergency in this guest lecture by Professor Giuseppe Grasso. Delve into the complex relationship between protein folding, misfolding, and neurodegenerative diseases. Examine the crucial role of the ubiquitin-proteasome system (UPS) in maintaining cellular health and its implications in disorders such as Alzheimer's Disease, Rett syndrome, and autism. Investigate the potential of proteasome modulation as a therapeutic target for neuronal disorders. Gain insights into novel holistic approaches aimed at addressing protein misfolding and neurodegenerative diseases. Learn from Professor Grasso's expertise as he presents a comprehensive overview of this pressing health concern and discusses innovative strategies for tackling conformational diseases.