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Tutorial series demonstrating how to use the Genomics2Proteins (G2P) Portal, a discovery tool developed by the Broad Institute that links genetic screening outputs to protein sequence and structure. Learn to visualize human genetic variations from databases like gnomAD, ClinVar, and HGMD alongside protein sequence annotations from UniProt, all pre-mapped on protein sequences and structures. Master interactive and automated mapping techniques for variations, protein features, and functional genomic assay readouts including saturation mutagenesis data. Explore comprehensive workflows starting from human gene/protein identifiers or protein structures, investigate protein-level effects of non-canonical transcript variants, and analyze conservation patterns in viral protein structures. Discover how to link genetic constraint scores to protein structures, map functional data for exploring protein-protein interactions in bacterial complexes, and analyze E3 ubiquitin ligase variants. Access training on the Protein Feature Viewer interface, learn to use G2P Portal APIs for large-scale bioinformatics applications, and work through practical case studies demonstrating real-world applications of this genomics-to-proteomics analysis platform.
