Gene Structure Heterogeneity and Loop Extrusion Drive Transcriptional Noise in Human Cells

Explore the molecular basis of transcriptional noise in human cells through this insightful seminar by Professor Nick Gilbert from the University of Edinburgh. Delve into computer simulations based on biophysical principles to predict 3D chromatin structure and transcriptional output genome-wide. Discover how genes adopt different 3D structures and how influential nodes within a locus control structural diversity. Examine the correlation between transcription and the formation of protein-mediated microphase separated clusters of promoters and enhancers. Understand how gene structure heterogeneity and loop extrusion determine transcriptional noise. Gain valuable insights into chromatin biology and its impact on gene expression variability within cell populations.