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Explore xenotransplantation as a revolutionary solution to organ shortage through this 58-minute webinar that examines the transplantation of gene-edited pig organs into humans. Delve into groundbreaking research conducted at NYU over three years, involving seven gene-edited pig organ transplants into brain-dead or living human recipients. Discover how researchers generated and integrated comprehensive omic datasets, including bulk RNA-seq from peripheral blood mononuclear cells, single-cell and single-nucleus RNA sequencing from tissues and blood, spatial transcriptomics, and targeted and untargeted proteomic and metabolomic profiling. Learn about the systematic collection of plasma and urine samples alongside frequent xenograft tissue biopsies to monitor physiological and immunological responses. Focus on blood proteomics and metabolomics analysis in xenotransplant recipients while understanding how integrative omics approaches can detect critical changes in these unique experimental settings. Gain insights into mass spectrometry methodologies for generating proteomics and metabolomics data, and understand how these advanced analytical techniques contribute to advancing xenotransplantation research for future compassionate use and first-in-human trials.
