From Pigs to Patients - The Omics Edge in Xenotransplantation

Explore the cutting-edge field of xenotransplantation through this 58-minute webinar that examines how omics technologies are revolutionizing pig-to-human organ transplantation research. Learn about the critical organ shortage crisis where only one in four waitlisted patients receive life-saving organs, and discover how xenotransplantation offers a promising solution. Delve into groundbreaking research conducted at NYU involving seven gene-edited pig organs transplanted into brain-dead or living humans over three years, generating comprehensive omics datasets including bulk RNA-seq, single-cell and single-nucleus RNA sequencing, spatial transcriptomics, and targeted and untargeted proteomic and metabolomic profiling. Understand the systematic approach to data collection involving daily plasma and urine samples alongside frequent xenograft tissue biopsies. Focus specifically on blood proteomics and metabolomics findings in xenotransplant recipients while examining how integrative omics approaches can detect crucial physiological and immunological changes in these unique experimental settings. Gain insights into the immune and physiological responses critical for advancing compassionate use applications and first-in-human trials, presented by Dr. Brendan Keating, Associate Professor in the Division of Transplantation at NYU Langone Health and leader of international genomics consortium iGeneTRAIN.