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Explore the neurophysiological foundations of obsessive-compulsive disorder (OCD) through this 26-minute webinar presented by Dr. Nicole Provenza, an assistant professor and McNair Scholar at Baylor College of Medicine's Department of Neurosurgery. Discover how deep brain stimulation (DBS) achieves clinical benefit in 66% of treatment-resistant OCD patients while examining the fundamental neurophysiological mechanisms underlying the relationship between OCD behavior and neural activity. Learn about cutting-edge research utilizing continuous intracranial recordings that have revealed neural biomarkers of clinical response after deep brain stimulation treatment. Examine the identification of neurophysiological biomarkers for acute OCD symptom exacerbations, mood and energy changes upon DBS activation, and long-term clinical response patterns. Understand how these biomarkers could guide therapeutic decision-making and serve as control signals for adaptive DBS systems. Gain insights into ethologically valid approaches to understanding real-world brain-behavior relationships through the integration of neural activity monitoring and deep phenotyping methodologies. Discover how this research aims to develop personalized stimulation strategies that more effectively guide brain activity and behavior toward healthy states in patients with cognitive and emotional disorders. The presentation offers PACE credits for registered Labroots members and provides practical applications for advancing neuromodulation treatments in treatment-resistant psychiatric conditions.
