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This lecture series features two talks by Dr. Ernesto Lupercio from CINVESTAV, scheduled for Friday, March 21, 2025, from 3pm-5pm at Ungar Building, Room 528B. The first talk explores Solomon Lefschetz's mathematical contributions and institutional leadership in the 20th century, highlighting his profound influence on Latin American mathematics, his direct impact, and the lasting legacy of his initiatives. The second talk presents a progress report on ongoing research at the intersection of knot theory and machine learning, discussing recent developments, challenges, and potential implications of applying computational techniques to problems in knot theory.