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Explore the cutting-edge field of chimeric antigen receptor (CAR) T cell therapy in this 25-minute webinar presented by Dr. Sarwish Rafiq, Assistant Professor in the Department of Hematology and Medical Oncology at Emory School of Medicine. Discover how CAR T cells, despite their remarkable clinical efficacy in hematological malignancies, face significant challenges in achieving durable complete responses and treating solid tumors. Learn about the complex immunosuppressive tumor microenvironments and checkpoint pathway exploitation that allow tumors to evade the immune system. Examine novel methods for creating CAR T cells enriched with memory phenotype T cells that demonstrate improved metabolic fitness for both hematological and solid tumor applications. Gain insights from Dr. Rafiq's translational research that uses mechanistic understanding of immune effector cell function against cancer cells in the tumor microenvironment to inform the development of innovative and effective cellular therapies. Understand the current limitations of CAR T cell therapy and explore potential solutions for enhancing their therapeutic potential across different cancer types.
