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Explore how cell fate emerges in dynamic environments through homeorhetic regulation mechanisms in this conference talk by Aneta Koseska from the International Centre for Theoretical Sciences. Delve into the complex interplay between cellular decision-making processes and environmental fluctuations, examining how cells maintain stable phenotypic trajectories despite changing conditions. Learn about the theoretical frameworks that describe how biological systems achieve robust cell fate determination through dynamic regulatory networks. Discover the mathematical principles underlying homeorhetic regulation, which allows cells to maintain functional stability while adapting to environmental perturbations. Understand how low-dimensional models can capture the essential dynamics of high-dimensional biological systems, particularly in the context of cellular differentiation and fate specification. Examine the role of feedback mechanisms and regulatory circuits in ensuring consistent cell fate outcomes across varying environmental conditions. This presentation is part of the "Unifying Theories in High-Dimensional Biophysics" program, which aims to develop common theoretical frameworks for understanding complex biological phenomena across multiple scales and systems.
