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Explore the groundbreaking discovery of VEXAS syndrome in this 58-minute cardiovascular grand rounds presentation by Dr. Peter Grayson. Learn about this newly identified autoinflammatory condition that affects the blood and immune system, understanding how it was discovered through genetic research and its clinical manifestations. Discover the diagnostic criteria, pathophysiology, and treatment approaches for this rare syndrome that primarily affects older men and can cause severe systemic inflammation. Gain insights into the research methodology that led to identifying VEXAS syndrome and its implications for patients with unexplained inflammatory conditions, while understanding how this discovery represents a significant advancement in the field of rheumatology and hematology.