Explore the fundamental principles of non-equilibrium dynamics in disordered quantum systems through this comprehensive lecture from the II School on Emergent Phenomena in Non-Equilibrium Quantum Many-Body Systems. Delve into the complex behavior of quantum many-body systems when they are driven away from thermal equilibrium, with particular focus on how disorder affects their dynamical evolution. Learn about the theoretical frameworks used to understand relaxation processes, thermalization, and the emergence of non-trivial steady states in disordered quantum matter. Examine key concepts including localization phenomena, many-body localization, and the interplay between disorder and interactions in determining the fate of quantum information and energy transport. Discover how disorder can fundamentally alter the approach to equilibrium and lead to novel phases of matter that have no equilibrium counterparts. Gain insights into current research directions and experimental realizations of these phenomena in various quantum platforms, from cold atomic gases to solid-state systems.