Characterization of Myeloid Cell Hyperactivation Syndrome and Survival Differences in Humanized NOG-EXL and NSG-SGM3 Mice

Learn about myeloid cell hyperactivation syndrome in humanized mouse models through this 42-minute webinar presented by Dr. Elinor Willis, a veterinary pathologist and fellow at the University of Pennsylvania's Comparative Pathology Core. Explore the characterization of myeloid cell hyperactivation syndrome in CD34+ hematopoietic stem cell-humanized NSG-SGM3 and NOG-EXL mice, including comprehensive histopathology data across various tissues. Discover critical differences in overall survival rates and severity of myeloid cell hyperactivation syndrome between these two super immunodeficient mouse strains that express human myeloid-stimulatory cytokines. Understand how these findings impact the selection of appropriate humanized immune system models for long-term research studies, particularly when working with mice that have been engrafted with human CD34+ hematopoietic stem cells to support improved expansion of human myeloid cell populations. Gain insights into the adverse events that can complicate the use of these valuable research models and learn strategies for optimizing their application in extended experimental protocols.