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Explore experimental models and practical applications in the field of biophotonics through this 59-minute conference talk delivered at ICBS2025. Delve into the intersection of biology and photonics as the speaker examines various experimental approaches used to study light-tissue interactions and their biomedical applications. Learn about cutting-edge research methodologies, optical techniques for biological imaging and diagnostics, and how photonic technologies are being applied to solve complex biological problems. Discover the latest developments in optical biosensors, photodynamic therapy, fluorescence imaging, and other biophotonic applications that are advancing medical diagnostics and treatment options. Gain insights into the experimental design considerations, model systems, and validation approaches essential for successful biophotonics research, making this presentation valuable for researchers, graduate students, and professionals working at the interface of optics, biology, and medicine.