Overview
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This course focuses on contributions of biochemistry toward an understanding of the structure and functioning of organisms, tissues, and cells. Topics include:
- Chemistry and functions of constituents of cells and tissues and the chemical and physical-chemical basis for the structures of nucleic acids, proteins, and carbohydrates.
- Basic enzymology and biochemical reaction mechanisms involved in macromolecular synthesis and degradation, signaling, transport, and movement.
- General metabolism of carbohydrates, fats, and nitrogen-containing materials such as amino acids, proteins, and related compounds.
NOTE: The first half of this course, taught by Prof. Yaffe, is available on the MITx platform as {{% resource_link "ecc701aa-4694-48fe-bf33-5234fe26ded2" "*7.05x Biochemistry: Biomolecules, Methods, and Mechanisms*" %}}. This OCW website provides content primarily from the second half with Prof. Vander Heiden, which focuses on metabolism.
Syllabus
- Lecture 12: Carbohydrates/Introduction to Membranes
- Lecture 19: Introduction to Metabolism/Polysaccharides/Bioenergetics/Intro Pathways
- Lecture 20: Bioenergetics/Intro Pathways/Glycolysis I
- Lecture 21: Glycolysis II/Regulation
- Lecture 22: Glucogenesis/Carbohydrate Storage/TCA Cycle I
- Lecture 23: TCA Cycle II
- Lecture 24: Lipids and Fatty Acid Oxidation
- Lecture 25: Oxidative Phosphorylation
- Lecture 26: Oxidative Phosphorylation/Photosynthesis I
- Lecture 27: Photosynthesis II/CO2 Assimilation
- Lecture 28: Pentose Phosphate Pathway
- Lecture 29: Lipid Synthesis
- Lecture 30: Nitrogen/Amino Acid Metabolism I
- Lecture 31: Amino Acid Metabolism II
- Lecture 32: Nucleotide Metabolism
Taught by
Prof. Matthew Vander Heiden and Prof. Michael Yaffe