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Vanderbilt University

OpenAI GPTs: Creating Your Own Custom AI Assistants

Vanderbilt University via Coursera

Overview

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In the era of Generative AI, the demand for personalized and specialized Generative AI assistants is skyrocketing. Large language models like GPTs have demonstrated their remarkable capabilities, but what if you could harness their power to create custom AI assistants tailored to your specific needs? Welcome to the world of custom GPTs, where you can build intelligent systems that understand your domain, speak your language, and solve your unique challenges. This cutting-edge course will guide you through the exciting journey of creating and deploying custom GPTs that cater to diverse industries and applications. Imagine having a virtual assistant that can tackle complex legal document analysis, streamline supply chain logistics, or even assist in scientific research and hypothesis generation. The possibilities are endless! Throughout the course, you'll delve into the intricacies of building GPTs that can use your documents to answer questions, patterns to create amazing human and AI interaction, and methods for customizing the tone of your GPTs. You'll learn how to design and implement rigorous testing scenarios to ensure your AI assistant's accuracy, reliability, and human-like communication abilities. Prepare to be amazed as you explore real-world examples built around a GPT for Travel and Business Expense Management. The examples show how a GPT can help users book flights, hotels, and transportation while adhering to company policies and budgets. Additionally, the GPT can help streamline expense reporting and reimbursement processes, ensuring compliance and accuracy. Whether you're a business leader, entrepreneur, developer, or educator, this course will equip you with the skills to harness the transformative potential of custom GPTs. Unlock new realms of productivity, innovation, and personalized experiences by building AI assistants that truly understand and cater to your unique needs. Enroll now and join the forefront of AI revolution, where you'll learn to create intelligent systems that not only comprehend but also anticipate and exceed your expectations.

Syllabus

  • Custom GPTs Fundamentals
    • In this module, you will learn the core concepts behind building custom GPTs, including how to shape a GPT’s behavior through instructions, add relevant external knowledge using retrieval-augmented generation (RAG), and bring these elements together into a more capable and personalized AI assistant. You will also explore how tools and actions expand what a custom GPT can do, and how frameworks such as CAPITAL, prompt patterns, and persona design can be used to shape its tone, behavior, and overall user experience.
  • THINK: Create Great GPTs (Part I)
    • In this module, you will learn how to make custom GPTs more reliable, useful, and human-centered by testing them systematically and designing better interaction patterns. You will explore how to build simple benchmarks and create meaningful test cases, including expected, ambiguous, and high-risk scenarios, to evaluate GPT performance over time. You will also examine techniques such as direct quotations, output templates, the Flipped Interaction Pattern, menu-based navigation, and feature toggles to structure responses, gather the right context, and guide users more effectively. Throughout the module, the focus is on building GPTs that support human reasoning, surface ambiguity, and direct users toward the right evidence, options, or human support when needed.
  • THINK: Create Great GPTs (Part II)
    • In this module, you will learn how to make custom GPTs safer and more reliable when users ask unclear, ambiguous, or risky questions. You will explore how to define boundaries and ‘escape valves’ so a GPT knows when not to answer directly, how to handle ambiguity, conflicting information, or gaps in knowledge sources and user prompts, and how to guide users more effectively through prompt patterns such as question refinement, alternative approaches, and cognitive verification. By the end of the module, you will understand how to design custom GPTs that remain helpful while reducing the risk of misleading, overconfident, or unsupported responses.

Taught by

Dr. Jules White

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4.8 rating at Coursera based on 766 ratings

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