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Peptide Stapling: How to use the staple library hydrocarbon and specialty chemistries to create covalent links at I+4 or I+7 positions.
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Classroom Contents
Peptide Modeling in MolSoft ICM-Pro Interactive Ligand Editor
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- 1 Peptide Mode: Enabling the "peptide mode" in the Ligand Editor to ensure continuous chain handling and correct backbone geometry.
- 2 Editing Tools: Step-by-step residue operations including inserting, deleting, replacing, and adding Acetyl/NH₂ caps.
- 3 Refinement & Minimization:
- 4 Peptide Stapling: How to use the staple library hydrocarbon and specialty chemistries to create covalent links at I+4 or I+7 positions.
