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The Molecular Landscape of Rejection: Using rejection associated transcripts as classifiers
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Classroom Contents
Innovations in Rejection Surveillance after Heart Transplantation
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- 1 Intro
- 2 Relevant Financial Relationship Disclosure Statement
- 3 Number of Adult and Pediatric Heart Transplants by Year and Location
- 4 Adult Heart Transplants Diagnosis
- 5 Adult Heart TransplantsKaplan-Meier Survival by Era
- 6 Innovations in Rejection Surveillance after Heart Transplantation
- 7 Invasive Monitoring Attenuation through Gene Expression (IMAGE) Trial
- 8 Combined Primary Endpoint
- 9 DNA the Molecule of Life
- 10 Cell-Free DNA (cfDNA) is Found in Circulating Blood
- 11 Cell-Free DNA to Detect Heart Allograft Acute Rejection Study
- 12 Longitudinal %ddcfDNA measures after transplant
- 13 biopsy graded rejection
- 14 Allograft dysfunction by echocardiography
- 15 What are the clinical implications?
- 16 Endomyocardial Biopsy (EMB)
- 17 Intrinsic Problems of the Current Pathology Approach to Diagnosis of Rejection
- 18 Common Histological Artefacts that Mimic Rejection
- 19 Intragraft mRNA Assessment of Rejection
- 20 How Molecular Analysis Works
- 21 The Molecular Landscape of Rejection: Using rejection associated transcripts as classifiers
- 22 Archetype Analysis
- 23 Comparing the A1,2,3 Archetypes for kidney, heart, and lung as estimated by expression of rejection-associated transcripts (RATs)
- 24 The INTERHEART Study
- 25 Updated rejection and Injury archetype diagnoses
- 26 Examples of Heart Transplant Endomyocardial Biopsy with updated MMDx-Heart Reports
- 27 Reconcile discrepancies: Injury Repair Response Associated Transcripts
- 28 MMDx Results according to ISHLT pathology grading (AMR)
- 29 ¡Box system potential for risk stratification
- 30 Identification and Characterization of Trajectories of Cardiac Allograft Vasculopathy: Study design
- 31 Latent class mixed modelling
- 32 Baseline characteristics
- 33 Identification of 4 trajectories of CAV
- 34 Validation of the 4 trajectories in Europe and in the US
- 35 Determinants of trajectories: multivariable analysis
- 36 On-line calculator
- 37 Summary
