Broad Institute Courses

Base Editing and Prime Editing: Precise Genome Modification Without DNA Breaks

Explore groundbreaking gene editing technologies: base editing and prime editing. Discover their therapeutic applications and advancements in precision DNA modification without double-strand breaks.

• YouTube
• 1 hour 10 minutes
• Self-Paced
• Free Video

Pharmacological Adaptation of Proteostasis to Ameliorate Aging-associated Degenerative Diseases - 2023

Explore proteostasis adaptation for aging-related diseases. Discover kinetic stabilizers, lysosomal flux enhancers, and autophagy activators as potential treatments for amyloidosis and neurodegenerative disorders.

• YouTube
• 58 minutes
• Self-Paced
• Free Video

RNA Modifications and Their Impact on Biological Regulation - Broad-MIT Seminar 2023

Delve into post-transcriptional RNA modifications, focusing on m6A methylation and demethylation. Explore their impact on biological regulation, mammalian development, and plant growth, with insights into new chemical sequencing methods.

• YouTube
• 1 hour 11 minutes
• Self-Paced
• Free Video

Cross-cohort Analysis via Cloud Genomics - MPG Primer

Dive into cross-cohort analysis using cloud genomics, exploring trusted research environments, methodologies, and tools for efficient genetic data processing and interpretation.

• YouTube
• 46 minutes
• Self-Paced
• Free Video

Computational Protein Design and De Novo Design of Proteins

Explore computational approaches for designing functional proteins, including surface pattern analysis and de novo topology exploration, with applications in vaccine design, T-cell therapies, and biosensors.

• YouTube
• 1 hour 35 minutes
• Self-Paced
• Free Video

High-Throughput In Silico Genetic Screen for 3D Genome Organization - Models, Inference and Algorithms

Explore cutting-edge approaches in 3D genome organization research, including in silico genetic screening and graph representation learning for analyzing multiscale chromatin structure.

• YouTube
• 1 hour 50 minutes
• Self-Paced
• Free Video

Single-Cell Spatiotemporal Modeling - From RNA Velocity to Spatial Transcriptomics

Explore single-cell spatiotemporal modeling with dynamo framework and Stereo-seq technology. Uncover insights into cellular states, transitions, and spatial dynamics in developmental biology and neuroscience.

• YouTube
• 52 minutes
• Self-Paced
• Free Video

Biomedical Science and Machine Learning - A Two-Way Street (2023)

Explore the convergence of biomedical science and machine learning, discovering how these fields synergize to address modern biological questions and drive innovations in data analysis.

• YouTube
• 1 hour 7 minutes
• Self-Paced
• Free Video

Learning to Read and Write Protein Evolution

Explore protein language models and their role in understanding evolutionary rules, predicting mutation effects, and guiding artificial evolution for antibody development and novel protein structures.

• YouTube
• 1 hour 3 minutes
• Self-Paced
• Free Video

MPG Primer: Intro to Terra - Hands on with Jupyter Notebooks in Terra - Part 2 of 3

Dive into hands-on Jupyter Notebooks in Terra with experts from the Broad Institute. Gain practical skills in medical and population genetics data analysis through interactive demonstrations and discussions.

• YouTube
• 48 minutes
• Self-Paced
• Free Video

Genetics of Inherited Retinal Degenerations

Explore genetic foundations of inherited retinal degenerations, including diagnosis, therapies, and research advancements. Gain insights into clinical applications and emerging treatments for eye disorders.

• YouTube
• 38 minutes
• Self-Paced
• Free Video

Learning Representations for Image-Based Profiling of Perturbations - MPG Primer 2023

Dive into image-based profiling of perturbations, exploring cell painting assays, morphology profiling, and machine learning techniques for predicting compound interactions and cell phenotypes.

• YouTube
• 42 minutes
• Self-Paced
• Free Video

Clinical Interpretation of Genes and Variants for Disease Causality - MPG Primer 2022

Dive into clinical interpretation of genes and variants for disease causality with expert Heidi Rehm. Explore standardized approaches, open science, and data sharing in genomic medicine and rare disease gene discovery.

• YouTube
• 1 hour 2 minutes
• Self-Paced
• Free Video

Learning Differentiation Dynamics from Lineage Tracing Datasets

Uncover robust computational approaches for inferring cell dynamics from single-cell transcriptomics integrated with lineage tracing, focusing on the CoSpar method and its applications in hematopoiesis and reprogramming.

• YouTube
• 54 minutes
• Self-Paced
• Free Video

Deep Learning-Based Morphological Profiling for Rare Disease Genomic Medicine

Explore deep learning-based morphological profiling for rare disease genomics. Uncover innovative approaches to overcome batch effects and improve out-of-distribution generalization in fluorescent microscopy data analysis.

• YouTube
• 1 hour 19 minutes
• Self-Paced
• Free Video