Coursera Spring Sale
40% Off Coursera Plus Annual!
Grab it
Learn about Wilson's Disease, a rare genetic disorder causing copper accumulation in the body, through this comprehensive 15-minute medical lecture designed for USMLE and NEET-PG exam preparation. Explore the pathophysiology of copper overload and understand how defective ATP7B protein leads to toxic copper deposits in the liver, brain, and other organs. Master the clinical presentations including hepatic manifestations like cirrhosis and liver failure, neurological symptoms such as tremors and movement disorders, and psychiatric changes including personality alterations and behavioral problems. Discover the classic diagnostic signs including Kayser-Fleischer rings in the cornea and learn to interpret key laboratory tests such as low serum ceruloplasmin levels and elevated 24-hour urinary copper excretion. Understand the step-by-step diagnostic approach and differential diagnosis considerations for this multisystem disorder. Review evidence-based treatment strategies including copper chelation therapy with penicillamine and trientine, zinc supplementation for maintenance therapy, and liver transplantation for end-stage disease. Gain insights into monitoring treatment response and managing potential side effects of therapeutic interventions. Perfect for medical students, residents, and healthcare professionals preparing for board examinations or seeking to strengthen their understanding of this important neurological and hepatological condition.
