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This 15-minute educational video from Kurzgesagt – In a Nutshell examines the science behind fentanyl, described as the deadliest illegal drug in US history. Discover what opioids do to the brain and body, the physiological effects of these substances, and why fentanyl creates a short-lived, inferior, and brutally addictive high compared to heroin. Learn about the alarming reality of fentanyl overdoses affecting people who never intentionally chose to take the drug. The video provides scientific explanations with Kurzgesagt's characteristic animation style, offering a balanced and informative look at a critical public health issue affecting communities worldwide.