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Explore the integration of quantum computing with high-performance classical computing in this 23-minute video that examines the heterogeneous computing paradigm essential for achieving quantum advantage. Learn about different compute resources and various programming workflows that leverage both quantum and classical systems, as quantum computing workflows inherently depend on classical computing components. Discover how solving the most challenging computational problems will require combining quantum processors with supercomputing infrastructure rather than replacing classical computers entirely. Follow a practical demonstration of sample-based quantum diagonalization (SQD) as an example application that showcases this integrated approach. Gain insights into the programming methodologies and architectural considerations necessary for effectively utilizing both quantum and high-performance classical computing resources in unified workflows designed to tackle complex computational challenges.