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Explore groundbreaking research findings on the pathophysiological mechanism behind multisystem inflammatory syndrome in children (MIS-C) in this World Shared Practice Forum Podcast. Delve into the characteristic immune response of MIS-C patients and gain insights into post-infectious auto-immune disease phenotypes. Learn to describe MIS-C pathophysiology, including clinical features and molecular immune response, and understand the immune dysregulation leading to MIS-C, focusing on autoantibodies and T-cell responses. Identify potential connections between SARS-CoV-2 infection and autoimmune responses, and recognize implications for related conditions like long COVID and sepsis. Presented by Drs. Adrienne Randolph and Aaron Bodansky, this 24-minute podcast offers valuable knowledge for healthcare professionals caring for critically ill children worldwide.