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Explore a detailed lecture by Professor Andrew Yurochko from Louisiana State University Health Services Center that delves into the complex mechanisms of Human Cytomegalovirus (HCMV) entry and dissemination. Learn about this significant pathogen, which ranks among the leading infectious causes of birth defects in the United States, affecting approximately 1 in 150-200 live births through congenital infection. Discover how HCMV, as a myelotropic virus, utilizes monocytes for host transmission and how this process relates to infection pathogenesis. Examine the intricate early infection stages, including cell surface receptor interactions, downstream signaling pathways, intracellular trafficking, and the resulting immunological responses. Gain insights into how the integration of immunological, virological, and cell biological approaches contributes to understanding these crucial infection mechanisms and potentially identifying new therapeutic targets.
