Two Genomes, One Balance: Mitochondrial and Nuclear DNA Stability

This lecture from Yale Cancer Center Grand Rounds explores the critical relationship between mitochondrial and nuclear DNA stability. Dr. Agnel Sfeir presents research on how these two genomic systems maintain balance within cells and the implications for cancer development and treatment. Discover the mechanisms that regulate DNA stability across both cellular compartments and learn about cutting-edge findings that connect mitochondrial function to nuclear genome integrity.