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This 14-minute educational video explores the nursing process for tumor lysis syndrome (TLS), an oncologic emergency characterized by severe metabolic and electrolyte abnormalities. Learn about this potentially life-threatening complication that typically occurs during treatment of hematological malignancies when chemotherapeutic medications rapidly kill large numbers of tumor cells. Discover how to apply the ADPIE nursing process (Assessment, Diagnosis, Planning, Implementation, and Evaluation) to effectively care for patients experiencing TLS. Produced by Osmosis, this comprehensive resource provides essential knowledge for current and future clinicians to recognize, manage, and prevent complications associated with tumor lysis syndrome in clinical practice.