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Explore the critical security challenges and requirements for implementing PCIe 6 switch deployments in this 16-minute conference talk from the Open Compute Project. Learn how to maintain end-to-end security as the industry transitions from PCIe 5 to PCIe 6, requiring coordinated approaches across devices, switches, and system architectures. Discover the essential alignment needed for end-to-end security and Confidential Compute scenarios in secure PCIe 6 deployments. Examine device-level security features including secure boot and attestation, while understanding system-wide trust boundaries and policy enforcement mechanisms. Understand the unique challenges introduced by PCIe 6's higher speeds and PAM4 signaling, which impact signal integrity, side-channel exposure, and authentication mechanisms. Gain valuable insights into the hardware and firmware dependencies that must be carefully coordinated to build secure and scalable PCIe 6 infrastructure capable of operating at 64 GT/s speeds.