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Explore receptor-mediated targeted drug delivery strategies for treating Alzheimer's disease in this 29-minute webinar presented by Dr. Rachita Sumbria, Associate Professor at Chapman University School of Pharmacy and Associate Project Scientist at UC Irvine. Learn about transferrin receptor-mediated delivery mechanisms that enable large molecules to cross the blood-brain barrier and reach brain tissue effectively. Discover how antibody-drug fusion proteins are engineered and delivered using this targeted approach, and examine their therapeutic effects demonstrated in mouse models of Alzheimer's disease. Understand the potential side effects associated with this delivery method and the significant challenges researchers face when implementing chronic dosing regimens for long-term treatment. Gain insights into the cerebrovascular basis of Alzheimer's disease and how targeted drug delivery systems can overcome traditional barriers to brain-directed therapeutics. The presentation covers both the scientific mechanisms underlying transferrin receptor targeting and practical considerations for translating these approaches into clinical applications for neurodegenerative disease treatment.
