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Explore the critical connection between gut microbiota and breast cancer metastasis in this 29-minute webinar presented by Dr. Melanie Rutkowski, an associate professor at the University of Virginia's department of Microbiology, Immunology, and Cancer Biology. Discover how an unhealthy and inflamed gut microbiome impacts long-term susceptibility to metastatic breast cancer, particularly in hormone receptor-positive (HR+) Her2-negative cases that represent 73.1% of metastatic breast cancer diagnoses. Learn about the paradoxical discovery of TLR5 signaling effects in tumor microenvironments and understand how commensal microorganisms influence anti-tumor immune function, tumor growth, and metastasis. Examine the immunological and metabolic pathways responsible for poor breast cancer outcomes and gain insights into the link between gut microbiota, mammary tissue microenvironment, and lung metastasis. Understand current research findings published in high-impact journals including Cancer Cell and Cancer Research, and explore potential therapeutic strategies for counteracting the microbiota's negative effects on immune system function during tumor progression. This presentation addresses the significant barrier of preventing metastatic dissemination in HR+ breast cancer patients, despite improved survival rates over recent decades.
