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Attend this 59-minute webinar featuring Dr. Robert Davey from Boston University's Chobanian & Avedisian School of Medicine and Director of the National Emerging Infectious Diseases Laboratories (NEIDL) as he presents groundbreaking research on Ebola virus infection mechanisms. Discover how researchers developed the first large-scale, image-based CRISPR knockout screen capable of operating in high-biocontainment environments to analyze the temporal program of Ebola virus infection at single-cell resolution. Learn about the innovative integration of high-content imaging, deep learning-driven phenotypic analysis, and time-resolved infection markers to map how specific host genes control discrete transitions in the viral life cycle, from entry and transcription to genome replication and egress. Explore the identification of both stage-specific regulators and multifunctional factors that influence multiple phases of infection, revealing new mechanistic insights and potential antiviral targets. Understand how this approach demonstrates the power of combining CRISPR screening with advanced imaging to deconvolve complex viral programs and provides a generalizable strategy for studying other high-consequence pathogens in real time. Participate in the live Q&A session to engage directly with Dr. Davey about his research on highly pathogenic viruses and the development of therapeutic countermeasures using cutting-edge molecular biology, pharmacology, and advanced imaging technologies.
