Explore the twistor approach to asymptotic symmetries and flat holography in this comprehensive lecture delivered by Tim Adamo at the Galileo Galilei Institute (GGI). Delve into the mathematical foundations and theoretical frameworks that connect twistor theory with the study of asymptotic symmetries in flat spacetime. Learn how these concepts contribute to our understanding of holographic principles in non-AdS settings, examining the relationship between boundary and bulk physics in asymptotically flat spacetimes. This first lecture in the series establishes fundamental concepts that will be built upon in subsequent sessions.