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Attend this colloquium lecture exploring the critical role of interfacial science in addressing climate change and energy challenges. Learn through two detailed case studies how fundamental interfacial science principles are engineered and applied in industrial scenarios, including applications in green hydrogen electrolyzers that support India's Energy Security Strategy. Discover methods for measuring the stability of nano-aggregates (asphaltenes) in oil products and understand how thermodynamic analysis provides solubility parameter estimation for complex hydrocarbon fluids, with potential applications in biofuel stability assessment. Gain insights from Professor Girish Rao's extensive 18-year career at Shell Technology Centre Bangalore, where he led product development and exploratory research teams, and his 15-year tenure at Unilever Research developing interface and colloid science innovations for detergent products. Explore how multidisciplinary technical solutions incorporating interfacial science can simultaneously increase energy supply for growing economies while decreasing atmospheric CO2 levels under cost constraints, and understand the transition of these approaches from oil product analysis to emerging biofuel technologies.