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The Evolving Story of PCSK9 - Cholesterol Homeostasis and Innate Immunity

University of Ottawa Heart Institute via YouTube

Overview

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Join this research conference to explore the multifaceted roles of PCSK9, a secreted protein crucial for cholesterol homeostasis and innate immunity. Discover how PCSK9 promotes degradation of liver LDL receptors, leading to elevated blood LDL-cholesterol levels and increased cardiovascular risk. Learn about the groundbreaking therapeutic applications of PCSK9 inhibition and its unexpected connections to inflammation and immune system function. Examine the latest research findings that reveal PCSK9's dual role beyond cholesterol regulation, including its involvement in innate immunity pathways. Gain insights from cutting-edge laboratory research on lipoprotein receptor biology and understand how this protein's inhibition has opened new therapeutic avenues. Explore the biochemical mechanisms underlying PCSK9's function and its implications for cardiovascular disease prevention and treatment strategies.

Syllabus

The evolving story of PCSK9 - Weekly Research Conference with Thomas Lagace, PhD

Taught by

University of Ottawa Heart Institute

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