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Learn about the challenges and opportunities presented by DNA's exceptional information storage capacity in this conference presentation from the 2025 Storage and Computing with DNA Conference. Explore how researchers are addressing the limitations of traditional chemical DNA synthesis, which becomes laborious and expensive for sequences exceeding 200 nucleotides, often resulting in low yields and incomplete sequences. Discover an innovative template-based enzymatic platform that overcomes these constraints by enabling efficient production of single-stranded DNA (ssDNA) sequences longer than 1kb while maintaining high fidelity and allowing site-specific modifications. Examine how this enzymatic approach eliminates the need for post-synthesis modification steps by incorporating custom modifications such as fluorescent dyes, biotin, or other chemical groups directly during synthesis. Understand the implications of this technology for synthetic biology, molecular diagnostics, nanotechnology, and gene therapy applications, and how it addresses the growing industrial and research demand for longer, customizable DNA sequences with improved scalability and workflow efficiency.
