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Explore advanced strategies for improving cancer immunotherapy effectiveness through a 31-minute webinar presented by Dr. Jia Shen, Assistant Professor at IU School of Medicine. Discover how targeting intrinsic pathways within cancer cells can overcome immunotherapy resistance, examining both regular differentiated cancer cells and cancer stem cells (tumor-initiating cells). Learn about the evolution of cancer treatment from traditional approaches like surgery, radiation, and chemotherapy to the revolutionary emergence of immunotherapy in the 2010s. Understand the current challenges facing immunotherapy, including initial and acquired resistance mechanisms. Gain insights into cutting-edge research methodologies including functional genomics, single-cell and spatial omics analyses, mouse models, and drug screening approaches used to unravel brain tumor development and treatment resistance mechanisms. Examine how patient-derived samples are being utilized to advance brain cancer research and develop innovative immunotherapies specifically targeting cancer stem cell characteristics. Understand the dual focus on regular cancer cells and cancer stem cells as distinct therapeutic targets for enhancing immunotherapy responses. The presentation covers Dr. Shen's research journey from biochemistry and molecular biology training to pharmaceutical drug development and current academic research focused on pioneering immunotherapies for adult and pediatric brain tumors.
